成体干细胞肺重建研究进展

成体干细胞来源广泛，无伦理争议，成为近几年的关注热点。研究表明以骨髓来源的间充质干细胞为代表的成体干细胞具有较强的多系分化潜能，可以广泛的参与包括肺在内的受损组织的修复与重建。在动物实验中已观察到，供体来源的成体干细胞可以定向分化为受损肺组织的多种功能细胞，并且有抑制纤维化等病变产生的能力。在本文中，回顾了近年来与肺损伤重建和疾病治疗相关的干细胞研究的最新进展，并探讨了成体干细胞治疗肺疾病与损伤的临床应用前景。

Adult Stem Cells and Lung Regeneration

Recent studies have identified the existence of adult stem cells in nearly all tissues,and enormous reports showed that adult stem cells have a greater differentiation potential than previously expected.Adult stem cells have been suggested to contribute to the repair and regeneration of injured lungs and ameliorate pulmonary fibrosis evidently in mice by homing to the injured tissue immediately after injury.Stem cells likely play key roles in the repair of diverse lung injuries.However,due to very low rates of cellular proliferation in vivo in the normal steady state,cellular and architectural complexity of the respiratory tract,and the lack of an intensive research effort,lung stem cells remain poorly understood compared to those in other major organ systems.The goal is to provide an overview of the stem cells within the lung and the adult stem cells that are believed to take place in the lung regeneration,and describe potential clinical applications with respect to human pulmonary disease.