Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size |
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Authors: | Zhivotovsky Lev A Underhill Peter A Feldman Marcus W |
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Institution: | N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia. levazh@gmail.com |
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Abstract: | Within a Y-chromosome haplogroup defined by unique event mutations, variation in microsatellites can accumulate due to their rapid mutation. Estimates based on pedigrees for the Y-chromosome microsatellite mutation rate are 3 or more times greater than the same estimates from evolutionary considerations. We show by simulation that the haplogroups that survive the stochastic processes of drift and extinction accumulate microsatellite variation at a lower rate than predicted from corresponding pedigree estimates; in particular, under constant total population size, the accumulated variance is on average 3-4 times smaller. |
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Keywords: | microsatellite Y chromosome mutation rate haplogroup |
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