Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase) |
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| Authors: | B Malfroy W J Kuang P H Seeburg A J Mason P R Schofield |
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| Institution: | Department of Pharmacological Sciences, Genentech, Inc., South San Francisco, CA 94080. |
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| Abstract: | We have isolated a cDNA clone encoding human enkephalinase (neutral endopeptidase, EC 3.4.24.11) in a lambda gt10 library from human placenta, and present the complete 742 amino acid sequence of human enkephalinase. The human enzyme displays a high homology with rat and rabbit enkephalinase. Like the rat and rabbit enzyme, human enkephalinase contains a single N-terminal transmembrane region and is likely to be inserted through cell membranes with the majority of protein, including its carboxy-terminus, located extracellularly. |
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