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Identification of two highly polymorphic CA-repeats (D21S1224 and D21S1261) on human chromosome 21q22.3 |
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| Authors: | Assumpció Bosch Jordi Guimerà Stefan Wiemann Wilhelm Ansorge David Patterson Xavier Estivill |
| Affiliation: | (1) Molecular Genetics Department, Cancer Research Institute (IRO), Hospital Duran i Reynals, E-08907, L'Hospitalet de Llobregat, Barcelona, Catalunya, Spain;(2) EMBL, Meyerhofstraße 1, D-69117 Heidelberg, Germany;(3) Eleanor Roosevelt Institute, 80206 Denver, CO, USA |
| Abstract: | Two highly polymorphic CA-repeat microsatellites (D21S1224 and D21S1261) are reported. The clones containing these CA-repeats (ABM-C60 and ABM-C29) have been isolated from a human chromosome-21-specific library (LA21NS01) and have been localised to the q22.3 band using a specific chromosome 21 somatic cell hybrid panel. Both polymorphisms showed heterozygosities of 0.83 in the unrelated reference parents from the Centre d'Etude du Polymorphisme Humain. These new markers should improve the map of the 21q22.3 region, which is believed to contain a large number of genes. |
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