|
|||||
|
|
The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: part 1. |
|
| Authors: | W L Cody C Cai A M Doherty J J Edmunds J X He L S Narasimhan J S Plummer S T Rapundalo J R Rubin C A Van Huis Y St-Denis P D Winocour M A Siddiqui |
| Affiliation: | Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105, USA. |
| Abstract: | Utilizing X-ray crystallography and molecular modeling, highly potent and selective peptidomimetic thrombin inhibitors have been designed containing a rigid piperazinedione template. The synthesis and biological activity of these compounds will be described. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |