Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X |
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Authors: | Kamocka Malgorzata Pollard Morris Suckow Mark Mielicki Wojciech P Rosen Elliot D |
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Institution: | Medical University of Lodz, Lodz, Poland. mkamocka@iupui.edu |
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Abstract: | Two common procoagulant activities associated with tumors are tissue factor and cancer procoagulant (CP), an activator of coagulation factor X. We have identified a convenient source of CP in transplanted Lobund-Wistar rat PA3 prostate tumors. CP activity was purified from 5 independent transplanted prostate tumors by column chromatography. The protein activated factor X in the absence of TF and factor VII. An antihuman CP antibody recognized rat CP in an ELISA and inactivated CP activity in a chromogenic assay. Lobund-Wistar prostate tumors may provide a convenient animal model useful in determining the role of CP in cancer development. |
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