Expression of chitin synthase genes during yeast and hyphal growth phases of Candida albicans |
| |
Authors: | J. L. Chen-Wu J. Zwicker A. R. Bowen P. W. Robbins |
| |
Affiliation: | Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139. |
| |
Abstract: | Chitin, the beta 1,4-linked polymer of N-acetylglucosamine, is a fibrous polysaccharide that in many yeasts helps to maintain the structure of the mother-bud junction and in filamentous fungi is often the major supporting component of the cell wall. We have previously described a Candida albicans chitin synthase, CHS1. The DNA and derived protein sequences of a second gene, CHS2, are presented and compared with previously published gene sequences. Northern blot analysis shows that strikingly different levels of synthase 1 and 2 expression occur during yeast and hyphal phases of Candida growth. |
| |
Keywords: | |
|
|