Gastrointestinal tract specific gene GDDR inhibits the progression of gastric cancer in a TFF1 dependent manner |
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| Authors: | Guanghui Chu Shengbin Qi Guodong Yang Kefeng Dou Jianjun Du Zifan Lu |
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| Institution: | Xijing Hospital of Digestive Diseases, and Department of Biochemistry and Molecular Biology, The State Key Lab of Cancer Biology, The Fourth Military Medical University, Changlexi Road No. 15th, Xi'an, 710032, China. |
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| Abstract: | The novel gene GDDR, also named trefoil factor interactions 1, is abundantly expressed in human gastric epithelial cells but significantly down-regulated in gastric cancer. In this study, we first demonstrated that GDDR was specifically expressed in the gastrointestinal tract epithelium, while suppressed in gastric cancer cells. Forced expression of GDDR suppressed the tumor growth as shown by MTT and xenograft assay. siRNA mediated TFF1 inhibition nearly blocked the growth inhibitory role of GDDR. In summary, our study suggested that gastrointestinal tract specific gene GDDR might inhibit gastric cancer growth in a TFF1 dependent manner. |
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