Hemispherically-Unified Surface Maps of Human Cerebral Cortex: Reliability and Hemispheric Asymmetries |
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| Authors: | Xiaojian Kang Timothy J Herron Anthony D Cate E William Yund David L Woods |
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| Institution: | 1. Human Cognitive Neurophysiology Lab, VA Research Service, Department of Veterans Affairs Medical Center, Martinez, California, United States of America.; 2. Department of Neurology and Center for Neuroscience, Sacramento, California, United States of America.; 3. UC Davis Center for Mind and Brain, Davis, California, United States of America.; Beijing Normal University, Beijing, China, |
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| Abstract: | Understanding the anatomical and structural organization of the cerebral cortex is facilitated by surface-based analysis enabled by FreeSurfer, Caret, and related tools. Here, we examine the precision of FreeSurfer parcellation of the cortex and introduce a method to align FreeSurfer-registered left and right hemispheres onto a common template in order to characterize hemispheric asymmetries. The results are visualized using Mollweide projections, an area-preserving map. The regional distribution, inter-hemispheric asymmetries and intersubject variability in cortical curvature, sulcal depth, cortical thickness, and cortical surface area of 138 young, right handed subjects were analyzed on the Mollweide projection map of the common spherical space. The results show that gyral and sulcal structures are aligned with high but variable accuracy in different cortical regions and show consistent hemispheric asymmetries that are maximal in posterior temporal regions. |
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