Identification and Characterization of a Novel Trans-membrane Protein Gene, pdh1, from Schizosaccharomyces pombe期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Identification and Characterization of a Novel Trans-membrane Protein Gene, pdh1, from Schizosaccharomyces pombe

Authors:	Iha Hidekatsu; Takimoto Mitsuhiro; Danjoh Inaho; Fujiyama Asao

Institution:	¹National Institute of Genetics 1111 Yata, Mishima, Shizuoka 411, Japan ²Niigata University Medical School 1 Asahimachi-dori 757, Niigata 951, Japan ³Human Genome Center, Institute of Medical Science, Tokyo University 4-6-1 Shiroganedai Tokyo 108, Japan

Abstract:	We have cloned a new gene, pdh1, from genomic DNA of fissionyeast Schizosaccharomyces pombe. pdh1 is actively transcribedas 1400-nucleotide mRNA in vegetatively growing cells and cancode for a 226 amino acid polypeptide (pdh1p). Computationalstructural prediction has revealed that the pdh1p is a highlyhydrophobic protein with seven transmembrane domains. The predictionhas also detected a possible C-kinase phosphorylation site withinthe longest hydrophilic loop.

Keywords:	fission yeast membrane protein transmembrane domain
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