Phylogenetic Study of Organic Anion Transfer from Plasma into the Liver |
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Authors: | R. I. LEVINE H. REYES A. J. LEVI Z. GATMAITAN I. M. ARIAS |
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Affiliation: | 1.Department of Medicine, Albert Einstein College of Medicine,Bronx Municipal Hospital Center,New York;2.Mount Desert Island Biological Laboratory,Salisbury Cove, Maine |
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Abstract: | THE discovery of two intracellular proteins, Y and Z, with the unique property of binding certain organic anions, may help to account for the selective and rapid transfer of bilirubin and various dyes, drugs, steroids and metabolites from plasma into the liver, which is known to occur among mammals1–3. In the rat, from which they were first isolated3, Y and Z have been shown to possess the following characteristics, (i) They selectively bind organic anions, such as bilirubin, sulphobromophthalein (BSP) and indocyanine green, in vivo and in vitro3, (ii) The principal organic anion binding protein, Y, is present predominantly in the liver3,4, (iii) The concentration of Y increases after administration of phenobarbital, DDT and other drugs and concomitantly the rate of organic anion transfer into the liver is increased5. Furthermore, in the newborn monkey, the concentration of Y and the transfer into the liver of BSP, as measured by plasma disappearance rates, are both low and subsequently increase6. We report here the results of a phylogenetic study involving various vertebrates. These results further support the theory that Y and Z are intracellular acceptors which facilitate the transfer of certain organic anions from plasma into the liver. |
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