Potential therapeutic effect of yeast killer toxin |
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| Authors: | Luciano Polonelli Rodolfo Lorenzini Flavia De Bernardis Giulia Morace |
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| Affiliation: | (1) Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, !["lsquo"]("/content/g040175u470627np/xlarge8216.gif") A. Gemelli!["rsquo"]("/content/g040175u470627np/xlarge8217.gif") , Università Cattolica del Sacro Cuore, L. go F. Vitro 1, I-00168 Rome;(2) Istituto Superiore di Sanità, Viale Regina Elena 299, I-00185 Rome, Italy |
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| Abstract: | Experimental infections were produced in guinea pigs, rabbits and dogs with lesions similar to those seen in human seborrheic dermatitis and otitis externa by cutaneous application of cultures of Malassezia furfur and M. pachydermatis. Infected animals were treated by topical application of a concentrated yeast killer toxin (Hansenula anomala UCSC 25F). Clinical recovery as well as negative mycological test cultures of infected animals proved to the clearly associated with the treatment by the killer toxin. |
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