Integrative analysis of large scale expression profiles reveals core transcriptional response and coordination between multiple cellular processes in a cyanobacterium |
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| Authors: | Abhay K Singh Thanura Elvitigala Jeffrey C Cameron Bijoy K Ghosh Maitrayee Bhattacharyya-Pakrasi Himadri B Pakrasi |
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| Affiliation: | (1) Department of Biology, Washington University, 63130 St. Louis, MO, USA;(2) Department of Electrical and Systems Engineering, Washington University, 63130 St. Louis, MO, USA;(3) Department of Mathematics and Statistics, Texas Tech University, 79409 Lubbock, TX, USA |
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| Abstract: | Background Cyanobacteria are the only known prokaryotes capable of oxygenic photosynthesis. They play significant roles in global biogeochemical cycles and carbon sequestration, and have recently been recognized as potential vehicles for production of renewable biofuels. Synechocystis sp. PCC 6803 has been extensively used as a model organism for cyanobacterial studies. DNA microarray studies in Synechocystis have shown varying degrees of transcriptome reprogramming under altered environmental conditions. However, it is not clear from published work how transcriptome reprogramming affects pre-existing networks of fine-tuned cellular processes. |
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