Structural transformations of arabinogalactan from the Siberian larch during mechanochemical processing and the biological properties of the products |
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| Authors: | E N Medvedeva N A Neverova T E Fedorova V A Babkin E S Meteleva A V Dushkin T G Tolstikova M V Khvostov M P Dolgikh |
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| Institution: | 1.Favorskii Institute of Chemistry, Siberian Branch,Russian Academy of Sciences,Irkutsk,Russia;2.Institute of Chemistry of Solid Body and Mechanochemistry, Siberian Branch,Russian Academy of Sciences,Novosibirsk,Russia;3.Novosibirsk Institute of Organic Chemistry, Siberian Branch,Russian Academy of Sciences,Novosibirsk,Russia |
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| Abstract: | It has been found by gel-penetrating chromatography and quantitative 13C NMR spectroscopy that mechanochemical processing of arabinogalactan isolated from the wood of the Siberian larch changes
the molecular mass distribution, monosaccharide composition, and the degree of branching of its macromolecules. This is due
to the partial destruction of polysaccharide macromolecules and subsequent recombination of resulting fragments. The intensity
of these processes depends on the conditions of mechanochemical processing. Based on the data of IR and 13C NMR spectra, the conclusion has been drawn that no functionalization of arabinogalactan macromolecules occurs under these
conditions. The toxicopharmacological properties of mechanically processed arabinogalactan have been studied. Its acute toxicity
is >5000 mg/kg. |
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