| Abstract: | By means of morphological methods changes in the wall of the stomach central part and in that of the bile bladder have been studied in 15 patients after a remote vagotomy (in 7-17 years). Material of biopsies and resections has been investigated. In the wall of the organs in question focal and diffuse mono- and plasmocytic infiltrates, leucocytic invasion of the mucous membrane epithelium, microerosions, microfocal hemorrhages in the external layers of the muscular sheath have been revealed. Inflammatory-degenerative and dystrophic changes are observed in the intramural ganglia, in large and small fasciculi of the muscular-intestinal nervous plexuses. In the tissues of the organs studied there are no myelin fibers, that are ++pre-ganglial and receptor conductors. The degeneration of these fibers after vagotomy and loss of connections in the organs investigated with the CNS are supposed to result in essential changes not only of the nervous trophic of tissues in all membranes and sheaths, but bring about changes in the intramural nervous apparatus itself. These changes, in their turn, cause imbalance + in the neurogumoral regulation and can be considered as the base of a number of postvagotomic structural-functional disturbances. |
