The role of neuropeptide processing enzymes in endocrine (prostate) cancer: EC 3.4.24.15 (EP24.15) |
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| Authors: | Swanson Todd A Kim Sandra I Myers Michael Pabon Amanda Philibert Keith D Wang Mina Glucksman Marc J |
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| Institution: | Midwest Proteome Center and the Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science/Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA. |
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| Abstract: | The zinc metalloendopeptidase EC3.4.24.15 EP24.15, thimet oligopeptidase], a neuropeptide processing enzyme, is central to the formation and degradation of many bioactive peptides in the neural proteome, and is highly expressed in normal prostate. EP24.15 actions are increased in androgen-dependent prostate cancer compared to androgen-independent; augmented by androgen treatment, and inhibited by clinical GnRH analogs. The "neural" prostate includes: neuropeptides, cognate receptors and processing enzymes regulating signaling of peptide-mediated neural inputs. |
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