Early passage primate cell immortality is independent of tumorigenicity |
| |
Authors: | John C Petricciani Inessa S Levenbook Dale E Wierenga Yihua Qi |
| |
Institution: | (1) World Health Organization, Geneva, Switzerland;(2) National Vaccine and Serum Institute, Beijing, China;(3) OBRR, CDB, Food & Drug Administration, 8800 Rockville Pike, 20205 Bethesda, Maryland |
| |
Abstract: | Summary Seven continuous primate cell lines were tested in three systems (nude mice, muscle organ culture, and soft agarose) for their
ability to express characteristics usually associated with malignant cell lines. Five of the seven cell lines failed to produce
tumors in nude mice, failed to show a tumor-like pattern of growth in muscle organ culture, and failed to produce colonies
in soft agarose. The remaining two cell lines showed different degrees of tumorigenicity in nude mice, and gave frankly positive
results in the twoin vitro assays. In addition, one of these lines appeared to progress from potential to overt tumorigenicity. We conclude that acquisition
of infinite life in primate cell lines is not invariably equivalent to the ability to form tumors. |
| |
Keywords: | tumorigenicity neoplastic conversion cell immortality |
本文献已被 SpringerLink 等数据库收录! |
|