Nuclear matrix association regions of rat alpha 2-macroglobulin gene |
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Authors: | T Ito Y Sakaki |
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Institution: | Research Laboratory for Genetic Information, Kyushu University, Fukuoka, Japan. |
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Abstract: | We have identified DNA fragments which bind specifically to the nuclear matrix in vitro, termed matrix association regions (MARs), in the first and fourth introns of rat alpha 2-macroglobulin gene. The MAR in the first intron is enriched with sequences closely related to the cleavage consensus of topoisomerase II, and contains the binding site of nuclear factor-alpha, a sequence-specific DNA binding protein reported previously. |
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