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Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5) |
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| Authors: | Tasler Stefan Kraus Jürgen Pegoraro Stefano Aschenbrenner Andrea Poggesi Elena Testa Rodolfo Motta Gianni Leonardi Amedeo |
| Institution: | 4SC AG, Martinsried, Germany. stefan.tasler@4sc.com |
| Abstract: | Based on a pharmacophore alignment on known non-competitive mGluR5 inhibitors applying 4SCan technology, a new lead series was identified and further structurally investigated. K(i)'s as low as around 100 nM were achieved. |
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