Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA.
Abstract:
Highlights? The response of Cdc25C to Cdk1 in Xenopus egg extracts is ultrasensitive ? The Hill coefficient for the response is astronomical (~11–32) ? Multisite phosphorylation accounts for some of the ultrasensitivity ? The Cdc25C and Wee1A responses account for the bistability of the mitotic trigger