Complexity and characteristic frequency studies in ECG signals of mice based on multiple scale factors |
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Authors: | XiaoDong Yang AiJun He Peng Liu TongFeng Sun XinBao Ning |
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Institution: | (1) Max Planck Institute for Experimental Medicine, Hermann-Rein Str. 3, 37075 Göttingen, Germany |
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Abstract: | Existing methods of physiological signal analysis based on nonlinear dynamic theories only examine the complexity difference
of the signals under a single sampling frequency. We developed a technique to measure the multifractal characteristic parameter
intimately associated with physiological activities through a frequency scale factor. This parameter is highly sensitive to
physiological and pathological status. Mice received various drugs to imitate different physiological and pathological conditions,
and the distributions of mass exponent spectrum curvature with scale factors from the electrocardiogram (ECG) signals of healthy
and drug injected mice were determined. Next, we determined the characteristic frequency scope in which the signal was of
the highest complexity and most sensitive to impaired cardiac function, and examined the relationships between heart rate,
heartbeat dynamic complexity, and sensitive frequency scope of the ECG signal. We found that all animals exhibited a scale
factor range in which the absolute magnitudes of ECG mass exponent spectrum curvature achieve the maximum, and this range
(or frequency scope) is not changed with calculated data points or maximal coarse-grained scale factor. Further, the heart
rate of mice was not necessarily associated with the nonlinear complexity of cardiac dynamics, but closely related to the
most sensitive ECG frequency scope determined by characterization of this complex dynamic features for certain heartbeat conditions.
Finally, we found that the health status of the hearts of mice was directly related to the heartbeat dynamic complexity, both
of which were positively correlated within the scale factor around the extremum region of the multifractal parameter. With
increasing heart rate, the sensitive frequency scope increased to a relatively high location. In conclusion, these data provide
important theoretical and practical data for the early diagnosis of cardiac disorders. |
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