Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis

Authors:	Monika Biniecka Aisling Kennedy Chin T Ng Ting C Chang Emese Balogh Edward Fox Douglas J Veale Ursula Fearon Jacintha N O'Sullivan

Affiliation:	(1) Translation Rheumatology Research Group, Dublin Academic Medical Centre, The Conway Institute of Biomolecular and Biomedical Research, St. Vincent’s University Hospital, Elm Park, Dublin 4, Ireland;(2) Department of Pathology, University of Washington, 1959 NE Pacific St, HSB k056, Seattle, WA 98195, USA;(3) Department of Surgery, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James’s Hospital, St James’s Hospital, St James’s Street, Dublin 8, Ireland

Abstract:	Introduction To examine the effects of tumour necrosis factor (TNF) blocking therapy on the levels of early mitochondrial genome alterations and oxidative stress.

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