The effect of culture conditions on the production of erythromycin by Saccharopolyspora erythraea in batch culture |
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| Authors: | S M Heydarian M D Lilly A P Ison |
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| Institution: | (1) The Advanced Centre for Biochemical Engineering, Department of Chemical and Biochemical Engineering, University College London, WC1E 7JE Torrington Place, London, UK |
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| Abstract: | Summary
Saccharopolyspora erythraea growth is inhibited when grown at a low constant dissolved oxygen tension (DOT) of 10% air saturation. However, the specific erythromycin production is virtually identical to that of a culture where the DOT did not fall below 65%. In addition, at constant DOT (10%) a stirrer speed of 750 rpm in a 7 litre causes mechanical damage to the mycelia in comparison with result at 500 rpm. |
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