Application of the Suzuki-Miyaura cross-coupling reaction for the modification of phenylalanine peptides |
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Authors: | Kotha Sambasivarao Lahiri Kakali |
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Institution: | Department of Chemistry, Indian Institute of Technology-Bombay, Mumbai, 400 076, India. srk@chem.iitb.ac.in |
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Abstract: | We have demonstrated an exceptionally simple and a useful methodology for modification of unusual phenylalanine peptides by adapting the building block approach using the Suzuki-Miyaura cross-coupling reaction as a key step. This strategy gave a good overall yield of various modified tri- and pentapeptides that may be useful to prepare various biologically active peptides in a short period of time. |
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Keywords: | Suzuki‐Miyaura coupling post‐translational peptide modifications boronic acids heterocycles combinatorial chemistry |
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