Synthesis, Biological Properties, and Structure-Activity Relationships of Quinoxaline Angiotensin II Receptor Antagonists |
| |
| Authors: | Kyoung Soon Kim Ligang Qian Kennet EJ Dickinson Carol L Delaney JEileen Bird Thomas L Waldron Suzanne Moreland |
| |
| Institution: | The Bristol-Myers-Squibb Pharmaceutical Research Institute P.O. Box 4000, Princeton, NJ 08543-4000 U.S.A. |
| |
| Abstract: | Quinoxaline heterocycle containing angiotensin II receptor antagonist analogs were prepared. All five analogs reported here display potent antagonistic activities and most interestingly, quinozaline bis-N-oxide 10 exhibits very potent activities both in binding and functional assays. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
