LC3-associated phagocytosis |
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| Authors: | Susana Romao Christian Münz |
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| Affiliation: | Viral Immunobiology; Institute of Experimental Immunology; University of Zürich; Zürich, Switzerland |
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| Abstract: | A recent report from our group has described that upon engulfment of pathogens, a subset of phagosomes is formed to preserve antigens for prolonged presentation on MHC class II molecules. The distinctive feature of these particular vesicles is their coating with LC3/Atg8, a key component of the autophagy machinery. Here we discuss the possible outcomes of LC3-associated phagocytosis and its implications in the context of immunity. |
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| Keywords: | Atg8/LC3 macroautophagy phagocytosis phagosomal maturation MHC class II |
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