| miRNA调控线粒体功能的研究进展 |
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| 引用本文： | 谭佳,肖晨,陈金娜,危当恒. miRNA调控线粒体功能的研究进展[J]. 生命的化学, 2020, 40(2): 250-255 |
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| 作者姓名： | 谭佳 肖晨 陈金娜 危当恒 |
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| 作者单位： | 南华大学心血管疾病研究所,动脉硬化学湖南省重点实验室,湖南省动脉硬化性疾病国际科技创新合作基地,衡阳医学院,南华大学,衡阳421001;南华大学附属第一医院儿科,南华大学,衡阳421001;南华大学心血管疾病研究所,动脉硬化学湖南省重点实验室,湖南省动脉硬化性疾病国际科技创新合作基地,衡阳医学院,南华大学,衡阳421001 |
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| 基金项目： | 国家自然科学基金项目(31670962)。 |
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| 摘 要： | MiRNA为小分子非编码RNA,通过与靶基因的相互作用调节靶基因的表达,参与调控细胞的多个生物学过程。本文综述了miRNA与线粒体生物合成、线粒体动力学、线粒体能量代谢、线粒体钙稳态、线粒体自噬间的关系及其调节机制,阐述了microRNA调节线粒体功能的研究进展。
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| 关 键 词： | miRNA 线粒体 能量代谢 线粒体自噬 |
Research progress of miRNA on mitochondrial function |
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| TAN Jia,XIAO Chen,CHEN Jinna,WEI Dangheng. Research progress of miRNA on mitochondrial function[J]. Chemistry of Life, 2020, 40(2): 250-255 |
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| Authors: | TAN Jia XIAO Chen CHEN Jinna WEI Dangheng |
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| Affiliation: | (Institute of Cardiovascular Disease,Key Laboratory for Arteriosclerology of Hunan Province,Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease,Hengyang Medical College,University of South China,Hengyang 421001,China;Department of Pediatrics,the First Affiliated Hospital University of South China,University of South China,Hengyang 421001,China) |
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| Abstract: | MiRNA is a small molecule non-coding RNA that regulates the expression of target genes by interacting with target genes and participates in the regulation of multiple biological processes in cells. This review summarized the relationship of miRNAs with mitochondrial biosynthesis, mitochondrial dynamics, mitochondrial energy metabolism, mitochondrial calcium homeostasis, mitophagy and the regulatory mechanisms.We also reviewed the research progress of microRNA regulation on mitochondrial function. |
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| Keywords: | miRNA mitochondrial energy metabolism mitophagy |
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