T-UCRs with digestive and respiratory diseases |
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Institution: | 1. School of Traditional Chinese Materia Medica; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China;2. XinJiang Institute of Chinese Materia Medica and Ethnodrug, Urumqi 830002, China;3. Physical Education College, Guangzhou University, Guangzhou 510006, China |
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Abstract: | From the perspective of histoembryology, the lung, gaster, and intestines that derived from the endoderm of the gastrula are structurally homologous. The interplay of intestines and lung in many pathologic changes is called the gut-lung axis. RNAs transcribed from ultraconserved regions (T-UCRs) are highly evolutionarily conserved in many mammalian genomes and have been found to be important in the pathogenesis and diagnosis of many diseases. More and more studies in recent years have shown that T-UCRs play important roles both in digestive and respiratory diseases. Taking the gut-lung axis as the entry point, this review summarizes the T-UCRs related to digestive and respiratory diseases in recent years. Meanwhile, these T-UCRs and their targets can lay a foundation for future drug research. |
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Keywords: | T-UCRs Gut-lung axis Lung Gaster Intestines |
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