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Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies
Affiliation:1. Department of Chemistry & Chemical Biology, McMaster University, Hamilton, Ontario L8S 4M1, Canada;2. Department of Psychiatry, WPIC, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA;1. Department of Radiology, University of Colorado Denver, Aurora, CO 80045, USA;2. Department of Medical Oncology, University of Colorado Denver, Aurora, CO 80045, USA;1. Department of Pharmaceutical Chemistry, Humera Khan College of Pharmacy, Relief Road, Oshiwara, Jogeshwari West, Pratiksha nagar, Mumbai, Maharashtra 400102, India;2. Head of Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy, Opp. Lalbagh Main Gate, Hosur Road, Bengaluru, Karnataka 560027, India;1. Department of Chemistry, Hashemite University, P.O. Box 150459, Zarqa 13115, Jordan;2. Department of Chemistry, The University of Jordan, Amman 11942, Jordan;3. Fachbereich Chemie der Universität Konstanz, Universitätstraße 10, D-78457 Konstanz, Germany;4. Chemistry Department, Yarmouk University, P.O. Box 566, Irbid, Jordan;5. Department of Chemistry, AN-Najah National University, Nablus, Occupied Palestinian Territory;1. Department of Medicinal Chemistry, School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, PR China;2. Department of Pharmacology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, PR China;1. Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia;2. Department of Virology, Pasteur Institute of Epidemiology and Microbiology, 14 Mira St., 197101, St. Petersburg, Russia;3. Saint Petersburg State University, 7/9 Universitetskaya nab.,199034, St. Petersburg, Russia;4. Ufa Institute of Chemistry Ufa Federal Research Center RAS, pr. Oktyabrya, 71, 450054 Ufa, Russia;1. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, People’s Republic of China;2. Department of Pharmaceutical Analysis, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, People’s Republic of China
Abstract:The synthesis of a lead anti-viral cyclopropyl carboxy acyl hydrazone 4F17 (5) and three sequential arrays of structural analogues along with the initial assessment and optimization of the antiviral pharmacophore against the herpes simplex virus type 1 (HSV-1) are reported.
Keywords:Cyclopropanes  Hydrazones  Anti-viral  HSV-1  Herpesvirus
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