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Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to ΔFosB homodimers and ΔFosB/JunD heterodimers
Affiliation:1. Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, United States;2. Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, United States;3. Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, United States;1. Department of Psychiatry, Columbia University Medical Center, New York, USA;2. Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, USA;3. Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA;4. Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA;1. Department of Chemistry, Shri Meenakshi Government College for Women (Autonomous), Madurai 625 002, India;2. Department of Laser Studies, School of Physics, Madurai Kamaraj University, Madurai 625 021, India;1. Department of Chemistry, J.N.T. University Hyderabad, Kukatpally, Hyderabad 500085, India;2. X-ray Crystallography Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
Abstract:
Keywords:ΔFosB homodimer  ΔFosB/JunD heterodimer  Chemical probes  High-throughput screening  Fluorescence polarization assay
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