Imidazolidine-2,4,5- and pirimidine-2,4,6-triones – New primary pharmacophore for soluble epoxide hydrolase inhibitors with enhanced water solubility |
| |
| Institution: | 1. Lomonosov Moscow State University, Department of Chemistry, Leninskie Gory, 1-3, Moscow 119991, Russia;2. IPAC RAS, Severnyi Proezd, 1, Chernogolovka, Moscow Region, 142432, Russia;3. Volgograd State Technical University, VSTU, Lenina Avenue, 28, Volgograd 400005, Russia;1. Pharmaceutical Institute, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany;2. Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, D-60438, Frankfurt Am Main, Germany;1. College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 34134, South Korea;2. DGMIF, New Drug Development Center, 80, Cheombok-ro, Dong-gu, Daegu 41061, South Korea;1. Department of Applied Bioscience, Faculty of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan;2. Department of Medicinal Chemistry, Hyundai Pharm Co., Ltd, Suwon, Gyonggi 443-270, Republic of Korea;3. Department of Entomology and Nematology, and UCD Comprehensive Cancer Center, University of California, One Shields Ave, Davis, CA 95616, USA |
| |
| Abstract: | A series of inhibitors of the soluble epoxide hydrolase (sEH) containing imidazolidine-2,4,5-trione or pirimidine-2,4,6-trione has been synthesized. Inhibition potency of the described compounds ranges from 8.4 μM to 0.4 nM. The tested compounds possess higher water solubility than their preceding ureas. Molecular docking indicates new bond between the triones and the active site of sEH that in part explain the observed potency of the new pharmacophores. While less potent than the corresponding ureas, the modifications of urea group reported herein yield compounds with higher water solubility, thus permitting easier formulation. |
| |
| Keywords: | Soluble epoxide hydrolase Epoxyeicosatrienoic acids Inhibitor Adamantane Urea Imidazolidine-2 4 5-trione Pirimidine-2 4 6-trione |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
