Cryo-EM as a powerful tool for drug discovery |
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Affiliation: | 1. Van Drie Research LLC, 109 Millpond, North Andover, MA 01845, USA;2. Department of Biological Sciences, Columbia University, New York, NY 10027, USA |
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Abstract: | The recent revolution in cryo-EM has produced an explosion of structures at near-atomic or better resolution. This has allowed cryo-EM structures to provide visualization of bound small-molecule ligands in the macromolecules, and these new structures have provided unprecedented insights into the molecular mechanisms of complex biochemical processes. They have also had a profound impact on drug discovery, defining the binding modes and mechanisms of action of well-known drugs as well as driving the design and development of new compounds. This review will summarize and highlight some of these structures. Most excitingly, the latest cryo-EM technology has produced structures at 1.2 Å resolution, further solidifying cryo-EM as a powerful tool for drug discovery. Therefore, cryo-EM will play an ever-increasing role in drug discovery in the coming years. |
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Keywords: | Cryo-EM Microscopy Structure-based drug design Drug discovery |
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