Modulation of DNA and RNA by PNA |
| |
| Institution: | 1. Trace Analysis and Biosensor Research Center, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;2. Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;3. Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;4. Department of Applied Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;5. Department of Physics, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;6. Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand;1. Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, Via Vivaldi 43, 81100 Caserta, Italy;2. Molecular Immunology and Immunoregulation, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS-Napoli, 80131 Naples, Italy;3. Department of Cardiothoracic and Respiratory Sciences, University of Campania “Luigi Vanvitelli”, Via Leonardo Bianchi c/o Ospedale Monaldi, 80131 Naples, Italy;4. Ceinge-Biotecnologie Avanzate S.c.a r.l., Via G. Salvatore 486, 80145 Napoli, Italy;5. Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, 80131 Napoli, Italy;1. Department of Therapeutic Radiology, Yale University, New Haven, CT 06510, USA;2. Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA;3. Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA;4. Department of Chemistry and Center for Nucleic Acids Science and Technology (CNAST), Carnegie Mellon University, Pittsburgh, PA 15213, USA;5. Department of Pathology, Yale University, New Haven, CT 06510, USA;6. Department of Genetics, Yale University, New Haven, CT 06510, USA |
| |
| Abstract: | Peptide nucleic acid (PNA), a synthetic DNA mimic that is devoid of the (deoxy)ribose-phosphate backbone yet still perfectly retains the ability to recognize natural nucleic acids in a sequence-specific fashion, can be employed as a tool to modulate gene expressions via several different mechanisms. The unique strength of PNA compared to other oligonucleotide analogs is its ability to bind to nucleic acid targets with secondary structures such as double-stranded and quadruplex DNA as well as RNA. This digest aims to introduce general readers to the advancement in the area of modulation of DNA/RNA functions by PNA, its current status and future research opportunities, with emphasis on recent progress in new targeting modes of structured DNA/RNA by PNA and PNA-mediated gene editing. |
| |
| Keywords: | Antisense Antigene Gene edit Oligonucleotide therapeutics Peptide nucleic acid |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
