Radioligands targeting purinergic P2X7 receptor |
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| Affiliation: | 1. Discovery Chemistry, Discovery Sciences, Janssen Research and Development, LLC, San Diego, CA, United States;2. Neuroscience, Janssen Research and Development, LLC, San Diego, CA, United States |
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| Abstract: | The purinergic P2X7 receptor (P2X7R) is an adenosine triphosphate (ATP) ligand-gated cationic channel receptor. P2X7R is closely associated with various inflammatory, immune, cancer, neurological, musculoskeletal and cardiovascular disorders. P2X7R is an interesting therapeutic target as well as molecular imaging target. This brief digest highlights the radioligands targeting P2X7R recently developed in drug discovery and molecular imaging agent development. |
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| Keywords: | Purinergic P2X7 receptor (P2X7R) Radioligands Drug discovery Molecular imaging Positron emission tomography (PET) Single photon emission computed tomography (SPECT) |
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