Inhibitors of the Zika virus protease NS2B-NS3 |
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| Institution: | 1. State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China;2. Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China;3. Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China;4. Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China;5. Department of Pathogen Biology, Hainan Medical University, Haikou, Hainan, Hong Kong, China;6. The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong, China;1. Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA;2. Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA;2. Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore;3. NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore;4. School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 636921, Singapore |
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| Abstract: | In recent years, the Zika virus has emerged from a neglected flavivirus to a health-threatening pathogen that causes epidemic outbreaks associated with neurological disorders and congenital malformations. In addition to vaccine development, the discovery of specific antiviral agents has been pursued intensely. The Zika virus protease NS2B-NS3 catalyses the processing of the viral precursor polyprotein as an essential step during viral replication. Since the epidemic Zika virus outbreak in the Americas, several inhibitors of this protease have been reported. Substrate-derived peptides revealed important structural information about the active site, whilst more drug-like small molecules have been discovered as allosteric inhibitors. |
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| Keywords: | Flavivirus Serine protease Peptides Allosteric inhibitors Antivirals |
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