Low-dimensional compounds containing bioactive ligands. Part XIV: High selective antiproliferative activity of tris(5-chloro-8-quinolinolato)gallium(III) complex against human cancer cell lines |
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| Institution: | 1. Department of Inorganic Chemistry, Institute of Chemistry, P. J. Šafárik University in Košice, Moyzesova 11, 040 01 Košice, Slovakia;2. Department of Biophysics, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic;3. Department of Inorganic Chemistry, Faculty of Science, Charles University, Hlavova 2030/8, 128 40 Prague 2, Czech Republic;4. Department of Ecology, Faculty of Humanities and Natural Sciences, University of Prešov, Ulica 17. novembra 1, 081 16 Prešov, Slovakia;5. Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 16610 Prague 6, Czech Republic;1. Tianjin Modern Vocational Technology College, Tianjin 300350, PR China;2. Tianjin Construction Engineering Technology Research Institute, Tianjin 300204, PR China;3. Jiangsu Vocational Institute of Architectural Technology, Xuzhou 221116, PR China;1. Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland;2. Biological and Chemical Research Centre, Chemistry Department, University of Warsaw, Żwirki i Wigury 101, 02-089 Warsaw, Poland;3. National Medicines Institute, Chelmska 30/34, 00-725 Warsaw, Poland;4. Faculty of Engineering, Hokkai-Gakuen University, Asahimachi, Toyohira-ku, Sapporo 062-8605, Japan;1. Guangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin, 537000, PR China;2. Department of Chemistry, Guilin Normal College, 21 Xinyi Road, Gulin, 541001, PR China;3. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, 15 Yucai Road, Guilin, 541004, PR China;1. Department of Inorganic Chemistry, Institute of Chemistry, P. J. Šafárik University in Košice, Moyzesova 11, 04154 Košice, Slovak Republic;2. Department of Inorganic Chemistry, National Research Center, P.O. 12622, 33 Elbohoth St. (Former Elthrir St.), Dokki, Giza, Egypt;3. Department of Biochemistry, Institute of Chemistry, P. J. Šafárik University in Košice, Moyzesova 11, 04154 Košice, Slovak Republic;4. Department of Biology and Ecology, Faculty of Science, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia;5. Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences University of Kragujevac, 69 Svetozara Markovica, 34000 Kragujevac, Serbia |
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| Abstract: | Four gallium(III) complexes, Ga(ClQ)3]⋅MeOH (1 – MeOH), Ga(ClQ)3] (1), Ga(BrQ)3] (2), Ga(dIQ)3] (3) and Ga(CQ)3] (4), were prepared (H-ClQ = 5-chloro-8-quinolinol, H-BrQ = 7-bromo-8-quinolinol, H-dIQ = 5,7-diiodo-8-quinolinol, H-CQ = 5-chloro-7-iodo-8-quinolinol) and characterised by elemental analysis, IR and NMR spectroscopy. Single crystal structure analysis of 1 – MeOH confirmed that the complex has a molecular structure with gallium(III) metal ion coordinated in mer-fashion by N- and O-donor atoms of three ClQ ligands. Stability of all complexes in DMSO was proved by 1H NMR spectroscopy. The in vitro antiproliferative activity of 1 was evaluated against the A2780, MBA-MB-231 and HCT116 cell lines. Complex 1 displays higher antiproliferative activity (IC50 values in the range 2.1–6 μm) compared to the ClQ ligand and cisplatin; and a significant selective antiproliferative potency (IC50 = 136 μm, for normal MRC5pd30 cell line). Radical scavenging experiments revealed that complex 1 exhibits the highest antioxidant activity of the prepared complexes as well as the ligands. |
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| Keywords: | 5-Chloro-8-quinolinol 7-Bromo-8-quinolinol 5 7-Diiodo-8-quinolinol 5-Chloro-7-iodo-8-quinolinol Gallium(III) complexes Antiproliferative activity Antiradical activity |
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