Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole against Meloidogyne incognita |
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| Affiliation: | 1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;2. China Crop Protection Industry Association, Beijing 100723, China;1. University of Navarra, School of Pharmacy and Nutrition, Department of Pharmaceutical Technology and Chemistry, Irunlarrea 1, 31008 Pamplona, Spain;2. Institute of Tropical Health, University of Navarra, Pamplona, Spain;3. Department of Biochemistry and Molecular Biology, Universidad de Alcalá, Carretera Madrid-Barcelona km 33,600, E-28871 Alcalá de Henares, Madrid, Spain;1. Food and Pharmacy College, Zhejiang Ocean University, Zhejiang, Zhoushan 316022, PR China;2. Key Laboratory of Natural Resource of the Changbai Mountain and Functiaonal Molecules, Ministry of Education, Yanbian University, Jilin Yanji 133000, China;1. School of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou 450000, PR China;2. Collaborative Innovation Center of Food Production and Safety, Henan Province, PR China;1. Department of Plant Pathology, The University of Agriculture, Peshawar, 25130, Khyber Pakhtunkhwa, Pakistan;2. Institute of Biotechnology and Genetic Engineering, The University of Agriculture, Peshawar, 25130, Khyber Pakhtunkhwa, Pakistan;3. Department of Poultry Sciences, The University of Agriculture, Peshawar;4. Department of Crop Protection, Institute for Sustainable Agriculture (IAS), Consejo Superior de Investigaciones Científicas (CSIC), Apartado 4084, 14080 Córdoba, Spain;5. Phytopharmaceutical and Nutraceutical Research Lab, Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan |
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| Abstract: | Based on the characteristic of benzo[d][1,2,3]thiadiazole to induce the systemic acquired resistance and improve the immunity of plants, benzo[d][1,2,3]thiadiazole was introduced into 1,2,3-benzotriazin-4-one, thirty-one novel 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole were designed and synthesized. Nematicidal activity showed that most of the synthesized compounds exhibited great inhibitory activity in vivo against Meloidogyne incognita at 20 mg/L. Among 31 tested compounds, A2 and A3 showed an excellent nematicidal activity with the inhibition rate of 50.4% and 53.1% at the concentration of 1.0 mg/L, respectively. The influence of substituent type and position was investigated. The relationship between structure and activity was also preliminary analyzed. |
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| Keywords: | 1,2,3-benzotriazin-4-one Plant activator Nematicidal activity |
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