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Discovery of 3-(benzofuran-2-ylmethyl)-1H-indole derivatives as potential autophagy inducers in cervical cancer cells
Affiliation:1. Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India;2. Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110002, India;3. Microbiology Division, Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram, India;4. Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Poojappura, Thiruvananthapuram 695 014, India;5. Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8501, Japan;1. Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan;2. Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan;3. Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto, Japan;4. Division of Biochemical System Engineering, Radioisotope Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan;5. Institute of Integrated Cell Material Sciences (iCeMS), Kyoto University of Advanced Study, Kyoto, Japan;1. Centre for Natural Products & Traditional Knowledge, CSIR – Indian Institute of Chemical Technology, Hyderabad 500007, India;2. Academi of Scientific and Innovative Research-Postal staff college Area, Sector 19, Kamla Nehru Nagar, Ghaziabad, Utter Pradesh 201002, India;3. Department of Applied Biology, CSIR – Indian Institute of Chemical Technology, Hyderabad 500007, India;4. Qstatix Private Limited, Hyderabad 500035, India;1. Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China;2. School of Basic Medical Science, Zhengzhou University, Zhengzhou 450001, China;3. The Academy of Medical Science, Zhengzhou University, Zhengzhou 450001, China;4. Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou 450001, China;5. Faculty of Science, The University of Melbourne, Victoria 3010, Australia;6. State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, Jiangsu, China;1. Dipartimento di Biotecnologie, Chimica e Farmacia, (Dipartimento d’Eccellenza 2018-2022), Università di Siena, Via A. Moro, I-53100 Siena, Italy;2. Dipartimento di Farmacia, Università di Pisa, Via Bonanno 6, I-56126 Pisa, Italy;3. Dipartimento di Scienze della Vita, Università di Siena, Via A. Moro, I-53100 Siena, Italy;4. Dipartimento di Farmacia, (Dipartimento d’Eccellenza 2018-2022), Scuola di Medicina e Chirurgia, Università di Napoli “Federico II”, Via D. Montesano 49, I-80131 Napoli, Italy;5. Dipartimento di Neuroscienze, Area del Farmaco e Salute del Bambino (NEUROFARBA), Università di Firenze, Viale G. Pieraccini 6, I-50139 Firenze, Italy;1. State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of China;2. Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, People’s Republic of China;3. College of Chemistry and Environmental Sciences, Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, Kashgar University, Kashgar 844000, People’s Republic of China;4. School of Medicine, Nankai University, Tianjin 300071, People’s Republic of China;5. Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea;6. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, People’s Republic of China;7. Kansei Fukushi Research Institute, Tohoku Fukushi University, Sendai 989-3201, Japan
Abstract:
Keywords:Autophagy  Cervical cancer  Benzofuran  Bisindolylmethane  Friedel-Crafts alkylation
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