Teratogenic Effects of the Organophosphorus Compound Fenchlorphos in Rabbits |
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| Authors: | Nafstad I Berge G Sannes E Lyngset A |
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| Institution: | 1.Department of Pharmacology and Toxicology, Norwegian College of Veterinary Medicine, the Norwegian Medicines Control Authority, and the Department of Laboratory Animal Services, National Institute of Public Health, P.O. Box 8146, Dep., Oslo 1, Norway
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| Abstract: | Fenchlorphos was administered orally in doses of 0, 12.5, 25 and 50 mg per kg to pregnant rabbits from day 6 to 18 of gestation. No effect on implantation efficacy, number of live fetuses, or fetal weight was observed. The incidence of major malformations such as cardiovascular and brain anomalies was, however, increased in the medicated groups. Major skeletal malformations were more frequent in the medicated groups; minor skeletal variation were about equal in all groups. Dose-relationship was observed for cardiovascular malformations and cerebellar hypoplasia. |
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