| 温石棉对人红细胞膜脂质及蛋白质影响的ESR研究 |
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| 引用本文： | 吴卫东,刘世杰,尹宏,邹曦露,万谦.温石棉对人红细胞膜脂质及蛋白质影响的ESR研究[J].生物物理学报,1994,10(3):421-425. |
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| 作者姓名： | 吴卫东 刘世杰 尹宏 邹曦露 万谦 |
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| 作者单位： | 北京医科大学劳动卫生学教研室，中国科学院生物物理所 |
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| 摘 要： | 用５ＮＳ、１６ＮＳ及ＭＳＬ标记人红细胞膜，观察了茫崖及涞温源石棉对膜脂质及蛋白质的影响。结果表明，两种温石棉均可增加膜表面层及深层脂质刚性，即致膜表、深层脂质流动性降低；同时可改变膜蛋白构象。两种温石棉时膜脂质及蛋白质的影响强度与其剂量有关。经柠檬酸铝处理后，温石棉的上述作用明显减弱。
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| 关 键 词： | 温石棉，膜脂质，膜蛋白质，ESR自旋标记，柠檬酸铝 |
ESR STUDIES ON EFFECTS OF CHRYSOTILE ON ERYTHROCYTE MEMBRANE LIPID AND PROTEIN |
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| Wu Weidong,Liu Shijie,Yin Hong.ESR STUDIES ON EFFECTS OF CHRYSOTILE ON ERYTHROCYTE MEMBRANE LIPID AND PROTEIN[J].Acta Biophysica Sinica,1994,10(3):421-425. |
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| Authors: | Wu Weidong Liu Shijie Yin Hong |
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| Abstract: | Effects of MC and LC asbotos on erythrocyte membrane lipid and protein labeled with 5NS,16NS and MSL respctively were studied. The adults delnonstlatal that both kinds of chrysotile could incite rnelnbrane rigidity at the depth of 5 and 16 carbons, indicating a decas of inelnbrane fluidity,and also altered the confonnation of cane proteins. The effects of chrysotile were dose dependent. Chrysotile fibers treated with aluminium citrated showed a weaker effect than the untreated. |
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| Keywords: | Chrysotile Membrane lipid Membrane protein ESR spin label Aluminium citrate |
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