The Effects of Dietary Ferric Iron and Iron Deprivation on the Bacterial Composition of the Mouse Intestine |
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Authors: | Geoffrey R Tompkins Norris L O'Dell Israel T Bryson Catherine B Pennington |
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Institution: | (1) Department of Oral Biology, Medical College of Georgia, Augusta, GA 30912-1126, USA, US |
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Abstract: | The influence of dietary ferric iron on the intestinal microbiota of mice was investigated with a view to promoting benign
lactic acid bacteria (which have minimal iron requirements) in order to enhance colonization-resistance potential. Three groups
of eight mice received a diet differing only in iron content, for a period of 12 weeks. Dietary iron deprivation resulted
in overall increased small intestinal bacterial populations, including lactic acid bacteria, but these differences were generally
not significant (p > 0.05). With the exception of coliforms, all examined bacterial groups (anaerobes, micro-aerophiles, lactobacilli, and enterococci)
were significantly (p < 0.05) elevated in the colons of iron-deprived mice. The relatively low numbers of total anaerobes in the colons of iron-replete
and iron-overloaded mice suggested that, as well as promotion of bacteria under iron-deprived condition, provision of ferric
iron suppressed bacteria, probably by oxidation of normally reduced environments.
Received: 13 October 2000 / Accepted: 20 December 2000 |
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