Author index for volume 31 |
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| Authors: | D.A. Campbell S.P. Staal E.K. Manders G.D. Bonnard R.K. Oldham L.A. Salzman R.B. Herberman |
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| Affiliation: | 1. Laboratory of Immunodiagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014 U.S.A.;2. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 U.S.A.;3. Laboratory of Biology of Viruses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 U.S.A. |
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| Abstract: | Kilham rat virus (KRV) was isolated from the lymphocyte cytopathic 13762 summary adenocarcinoma tumor line described in part I of this report, as well as three other in vivo passaged rat tumors maintained in the same animal room. It could not, however, be isolated from the noncytopathic (CS8NT)D tissue culture line. Tests done with CsCl2-purified KRV preparations showed that the virus could replicate in rat lymphocytes and could profoundly depress lymphocyte viability and lymphoproliferative responses. Heterologous anti-KRV antiserum could reverse the inhibitory effects of the purified virus preparation and the inhibitory effects of ultrasonically disrupted KRV-infected tumor cells, but could only partially reverse the inhibitory properties of X-irradiated whole 13762 tumor cells. The results suggest that KRV could account for some, if not all, of the inhibitory properties of the 13762 tumor line. |
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| Keywords: | Address reprint requests to D. A. Campbell Laboratory of Immunodiagnosis National Cancer Institute Building 10 Room 8B11 Bethesda Maryland 20014. |
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