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The effects of corticosteroid concentrations on lymphocyte blastogenesis
Authors:Max L Webel  Roy E Ritts
Institution:1. Department of Nephrology, Walter Reed Army Institute of Research, Washington, D.C. 20012 U.S.A.;2. Department of Microbiology, Mayo Clinic and Foundation, Rochester, Minnesota 55901 U.S.A.
Abstract:High concentrations of methylprednisolone added for prolonged periods in vitro to lymphocyte cell cultures inhibited allogeneic-cell-induced or phytohemagglutinin (PHA)-induced blastogenesis in contrast to lower concentrations which were inhibitory only if added before or within several hours of blastogenic induction.
Keywords:Reprint requests should be addressed to Dr  Ritts at Department of Microbiology  Mayo Clinic  Rochester  Minnesota 55901  
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