Cytotoxic activity, X-ray crystal structures and spectroscopic characterization of cobalt(II), copper(II) and zinc(II) coordination compounds with 2-substituted benzimidazoles |
| |
Authors: | Obdulia Snchez-Guadarrama Horacio Lpez-Sandoval Francisco Snchez-Bartz Isabel Gracia-Mora Herbert Hpfl Norh Barba-Behrens |
| |
Institution: | aDepartamento de Química Inorgánica, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, México, D.F. 04510 México, Mexico;bCentro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. 1001,62209, Cuernavaca, Morelos, Mexico |
| |
Abstract: | Herein we present the synthesis, structural and spectroscopic characterization of coordination compounds of cobalt(II), copper(II) and zinc(II) with 2-methylbenzimidazole (2mbz), 2-phenylbenzimidazole (2phbz), 2-chlorobenzimidazole (2cbz), 2-benzimidazolecarbamate (2cmbz) and 2-guanidinobenzimidazole (2gbz). Their cytotoxic activity was evaluated using human cancer cell lines, PC3 (prostate), MCF-7 (breast), HCT-15 (colon), HeLa (cervic-uterine), SKLU-1 (lung) and U373 (glioblastoma), showing that the zinc(II) and copper(II) compounds Zn(2mbz)2Cl2]·0.5H2O, Zn(2cmbz)2Cl2]·EtOH, Cu(2cmbz)Br2]·0.7H2O and Cu(2gbz)Br2] had significant cytotoxic activity. The isostructural cobalt(II) complexes showed not significant activity. The cytotoxic activity is related to the presence of halides in the coordination sphere of the metal ion. Recuperation experiments with HeLa cells, showed that the cells recuperated after removing the copper(II) compounds and, on the contrary, the cells treated with the zinc(II) compounds did not. These results indicate that the mode of action of the coordination compounds is different. |
| |
Keywords: | Coordination compounds Cobalt(II) Copper(II) Zinc(II) Cytotoxic activity 2-Substituted benzimidazoles |
本文献已被 ScienceDirect 等数据库收录! |
|