Synthesis and structure-activity relationships of adenosine analogs as inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Modifications at positions 5′ and 8期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis and structure-activity relationships of adenosine analogs as inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Modifications at positions 5′ and 8

Authors:	Alex M. Aronov Michael H. Gelb

Affiliation:	^a Department of Chemistry, University of Washington, Seattle, WA 98195, U.S.A. ^b Department of Biochemistry, University of Washington, Seattle, WE 98195, U.S.A.

Abstract:	A number of 5′, N⁶- and C⁸, N⁶-disubstituted adenosine analogs was synthesized and tested for inhibition of trypanosomal glyceraldehyde 3-phosphate dehydrogenase. The most active compound, N⁶-(3-methyl-2-butenyl)-8-(2-thienyl)adenosine, had K_i of 9 μM and was marginally selective for the parasite enzyme.

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