An oxalyl-CoA synthetase is important for oxalate metabolism in Saccharomyces cerevisiae |
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Authors: | Justin Foster Paul A Nakata |
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Institution: | USDA-ARS Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St., Houston, TX 77030-2600, United States |
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Abstract: | Although oxalic acid is common in nature our understanding of the mechanism(s) regulating its turnover remains incomplete. In this study we identify Saccharomyces cerevisiae acyl-activating enzyme 3 (ScAAE3) as an enzyme capable of catalyzing the conversion of oxalate to oxalyl-CoA. Based on our findings we propose that ScAAE3 catalyzes the first step in a novel pathway of oxalate degradation to protect the cell against the harmful effects of oxalate derived from an endogenous process or an environmental source. |
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Keywords: | Degradation Oxalate Oxalyl-CoA Acyl-activating |
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