miR-34a expands myeloid-derived suppressor cells via apoptosis inhibition |
| |
Authors: | Anfei Huang Haitao Zhang Si Chen Fei Xia Yi Yang Fulu Dong Di Sun Sidong Xiong Jinping Zhang |
| |
Institution: | 1. Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, Jiangsu Province, People?s Republic of China;2. Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215021, Jiangsu Province, People?s Republic of China |
| |
Abstract: | Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population and show significant expansion under pathological conditions. microRNA plays important roles in many biological processes, whether microRNAs have a function in the expansion of MDSCs is still not very clear. In this study, miR-34a overexpression can induce the expansion of MDSCs in bone marrow chimera and transgenic mice model. The experimental results suggest that miR-34a inhibited the apoptosis of MDSCs but did not affect the proliferation of MDSCs. The distinct mRNA microarray profiles of MDSCs of wild type and miR-34a over-expressing MDSCs combined with the target prediction of miR-34a suggest that miR-34a may target genes such as p2rx7, Tia1, and plekhf1 to inhibit the apoptosis of MDSCs. Taken together, miR-34a contributes to the expansion of MDSCs by inhibiting the apoptosis of MDSCs. |
| |
Keywords: | Myeloid-derived suppressor cells miR-34a Expansion Apoptosis |
本文献已被 ScienceDirect 等数据库收录! |
|