Cell fate control in the developing central nervous system |
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Authors: | Nicolas Gué rout,Xiaofei LiFanie Barnabé -Heider |
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Affiliation: | Department of Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden |
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Abstract: | The principal neural cell types forming the mature central nervous system (CNS) are now understood to be diverse. This cellular subtype diversity originates to a large extent from the specification of the earlier proliferating progenitor populations during development. Here, we review the processes governing the differentiation of a common neuroepithelial cell progenitor pool into mature neurons, astrocytes, oligodendrocytes, ependymal cells and adult stem cells. We focus on studies performed in mice and involving two distinct CNS structures: the spinal cord and the cerebral cortex. Understanding the origin, specification and developmental regulators of neural cells will ultimately impact comprehension and treatments of neurological disorders and diseases. |
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Keywords: | Progenitors Neurogenesis Gliogenesis Ependymal cells Stem cells |
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