miR-329 suppresses the growth and motility of neuroblastoma by targeting KDM1A |
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Authors: | Haifeng Yang Qi Li Wohua Zhao Dun YuanHongyang Zhao Yong Zhou |
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Affiliation: | Department of Neurosurgery, West Division of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430056, China |
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Abstract: | MicroRNAs (miRNAs) act as key regulators of multiple cancers. miR-329 functions as a tumor suppressor in some malignancies. However, its role in neuroblastoma remains poorly understood. We found that miR-329 was decreased in metastatic tumor tissues compared with matched primary tumor tissues. Forced overexpression of miR-329 substantially suppressed cell proliferation, colony formation, migration, and invasion of neuroblastoma cells. Lysine-specific demethylase 1 (KDM1A) was found to be a target of miR-329. Furthermore, down-regulation of KDM1A by shRNA performed similar effects with overexpression of miR-329. Overexpression of KDM1A partially reversed the tumor suppressive effects of miR-329 in neuroblastoma cells. Collectively, miR-329 may suppress neuroblastoma cell growth and motility partially by targeting KDM1A. |
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Keywords: | miR-329 Neuroblastoma Growth Migration Invasion KDM1A |
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