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Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development
Authors:Laura Mangiavini,Christophe Merceron,Elisa Araldi,Richa Khatri,Rita Gerard-O&rsquo  Riley,Tremika LeShan Wilson,Erinn B. Rankin,Amato J. Giaccia,Ernestina Schipani
Affiliation:1. Department of Orthopaedic Surgery, Medical School, University of Michigan, Ann Arbor, MI 48109, USA;2. Division of Endocrinology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN 46202, USA;3. Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA;4. Department of Orthopaedic and Traumatology, Milano-Bicocca University, 20900 Monza (MB), Italy;5. Inserm, UMRS 791-LIOAD, Centre for Osteoarticular and Dental Tissue Engineering, Group STEP ‘Skeletal Tissue Engineering and Physiopathology’, 44042 Nantes, France;6. LUNAM, Nantes University, Faculty of Dental Surgery, Nantes, France;g Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University, Stanford, CA 94303-5152, USA;h Division of Endocrinology, Department of Medicine, Medical School, University of Michigan, Ann Arbor, MI 48109, USA
Abstract:
Keywords:Endochondral bone development   Limb bud mesenchyme   Von Hippel&ndash  Lindau   Hypoxia Inducible Factor
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